The 40-day cytisine treatment for smoking cessation: the Italian experience.
More details
Hide details
Italian Society of Tobaccology (SITAB), Bologna, Italy
Sapienza University, Department of Public Health and Infectious Diseases, Rome, Italy
Smoking Cessation Center, S. Camillo-Forlanini Hospital, Rome, Italy
Smoking Cessation Center, Hospital Careggi, Florence, Italy
Smoking Cessation Center, Humanitas Institute, Milan, Italy
Addiction Center, Azienda Socio-Sanitaria Territoriale Lecco, Italy
Smoking Cessation Center, Azienda Socio-Sanitaria Territoriale Vimercate Monza-Brianza, Italy
Publish date: 2017-05-25
Submission date: 2017-04-27
Acceptance date: 2017-04-28
Tob. Prev. Cessation 2017;3(May Supplement):72
In Eastern Europe, cytisine has been used a lot in smoking cessation while in Italy, it has only recently been introduced, however using a longer treatment schedule consisting of 40 days instead of 25 and a different posology. This work gathered the retrospective observational data collected by some Italian smoking cessation centers that used the 40 day cytisine treatment (40-DCT) and focused on short-term results and possible adverse events.

Material and Methods:
In Italy, cytisine (1.5 mg per tablet) was prescribed as galenical formulation because is not licensed with a specific brand. The dosing regimen was: induction (2 to 6 tablets/day for the first 7 days), maintenance (6 tablets/day for 7 days), and gradual reduction for 26 days. The 40-DCT was integrated with a behavioral support (5-7 meetings/patient). Demographic and clinical variables of patients were collected at the beginning and at the end of treatment.

A total of 162 patients (43.2% male) were treated with the 40-DCT, their mean-age was 51.1 years. They smoked 22.6 cigarettes/day and had a mean respiratory CO of 22 ppm at start. The quitting rate at end of treatment was 61%, while 26.0% dropped-out. Among those who continued to smoke (13%), about half of them (6%) halved the number of cigarettes. Nobody interrupted the treatment and only few patients had minor side effects.

The 40-DCT was effective in tobacco addiction treatment and well tolerated. The vegetal origin and the low cost of cytisine may increase its acceptability and help smokers to quit.

Maria Sofia Cattaruzza   
Dept. of Public Health and Infectious Diseases, Sapienza University, Rome, Italy, P.le Aldo Moro 5, 00185 Rome, Italy