Electronic or e-cigarettes are battery-powered devices that are used to vaporize a propylene glycol and vegetable glycerin solution, generally with some type of flavoring, and which may also contain liquid nicotine in various concentrations. Vape shops specialize in the distribution, marketing, and sale of e-cigarettes and related paraphernalia. As the vape shop industry begins to be regulated by public agencies, it becomes imperative to engage in research on this new modality of sales of e-cigarette products and understand its functions and, potentially, its reactions to regulations. There are rather few currently published peer-reviewed papers in this arena. This Special Issue will greatly increase the pool of research papers in this arena, and provide marketing, vaping behavior, and policy-related information from vape shops and their customers located in the United States. This is the first Issue of its kind on vape shops.