INTRODUCTION

Smokeless tobacco (SLT) is a major contributor to the global tobacco burden, with over 300 million people using SLT products worldwide1. The World Health Organization’s Framework Convention on Tobacco Control (FCTC) defines smokeless tobacco as ‘tobacco that is consumed in unburnt form either orally or nasally’2. SLT use is associated with a wide range of adverse health outcomes, including oral, oesophageal, and pancreatic cancers, as well as an increased risk of heart disease and stroke3. Globally, SLT use contributes to over 0.65 million deaths annually4. While global tobacco control efforts have largely focused on smoking cessation, SLT cessation remains under-researched, particularly in the South Asian Region, where SLT use surpasses smoking5.

Globally, the control measures are primarily smoking-centered even though countries like India and Bangladesh bear a significant SLT burden6-8. In India, 21.4% of the population uses SLT, which is more than double the smoking prevalence of 10.7%9. SLT use in India is higher among men (men 29.6% vs women 12.8%) and predominantly concentrated in rural areas (urban 15.2% vs rural 24.6%)10. As per the National Family Health Survey (NFHS)-5 (2019–2021), the most common form of tobacco consumption among men is chewing paan masala or gutkha (14.6%), followed closely by cigarettes (13.2%) and khaini (12.1%)11. SLT is consumed in various forms in India, including khaini, paan masala with tobacco, gutka, and betel quid with tobacco10. Similarly, in Bangladesh, 20.6% of the adult population uses SLT, with 24.8% of them being women12. The socio-cultural acceptance of SLT in both countries presents a significant public health challenge13.

Despite legislative measures such as India’s ban on gutka10 and Bangladesh’s prohibition of SLT advertising7, the prevalence of SLT use remains disproportionately high in these countries. Several barriers hinder SLT cessation, with demographic factors and intentions to quit playing a critical role. Previous studies indicate that SLT use is more prevalent among older adults13,14, individuals with a lower level of education9, those in lower wealth quintiles, and those with greater exposure to SLT marketing15.

The Global Adult Tobacco Survey (GATS) is a nationally representative survey developed by WHO and CDC to monitor tobacco use and key control indicators among adults aged ≥15 years. Several countries have participated in two waves of this survey16. A study in Bangladesh comparing two GATS waves (2009 and 2017) reported that among adults who used SLT, those in the older age category (aged ≥65 years) and women, were less likely to intend to quit in the future, whereas those with higher education and the highest wealth quintiles were more likely to intend to quit in the future17.

Advice and support from healthcare providers is a well-recognized facilitator of tobacco cessation. Some studies have demonstrated a strong and consistent association between receiving advice from a healthcare professional and increased likelihood of attempting to quit smokeless tobacco18,19. This form of intervention is especially critical in countries with high tobacco use prevalence, as it provides adults who use SLT with both motivation and guidance to initiate cessation. Despite this, the coverage and effectiveness of such interventions for those who use SLT remain underexplored, particularly in low- and middle-income countries.

Despite the introduction of various tobacco control measures, enforcement remains a persistent challenge in both India and Bangladesh. While some studies have explored smoking cessation, there remains a limited body of evidence specifically focused on the facilitators and barriers to smokeless tobacco (SLT) cessation, particularly in the context of temporal changes across GATS waves.

This study aims to address this gap by systematically analyzing the key demographic, healthcare, and policy-related factors influencing SLT cessation in India and Bangladesh. It applies a new way of presenting multivariate decomposition analysis to not only assess whether these factors are associated with changes in quit attempts, but also to quantify the relative contribution of each factor to observed changes over time. The findings are expected to generate policy-relevant insights that can support the design of more targeted and effective SLT cessation interventions in both countries and in other similar contexts.

METHODS

Overview

This study involved a secondary analysis of GATS data from two waves conducted in India and Bangladesh. The total number of GATS participants which were aged ≥15 years, the proportion who used SLT currently or in the past 12 months (either daily or less than daily), and among them, the proportion who provided valid responses to questions on attempting to quit SLT (AQSLT) were compared. Only individuals with valid AQSLT responses were included in further analysis. While de-identified data were used, an ethical approval to conduct the analysis was granted by the Public Health Foundation of India Institutional Ethics Committee (Ref. TRC-IEC 479/21).

Data

This study used data from two waves of GATS conducted in India (2009–2010 and 2016–2017) and Bangladesh (2009 and 2017). GATS uses a standardized interviewer-administered questionnaire and methodology across participating countries to ensure cross-country comparability in collecting self-reported data on both smoked and smokeless tobacco use, including prevalence, cessation behavior, and media messaging, making it a valuable tool for understanding patterns and determinants of SLT use at the population level16,20. The datasets are publicly accessible along with details of sampling procedures and data collection methods through the GTSS Data Portal (see Data Availability section).

Outcome variable

The outcome variable, attempted quitting smokeless tobacco (AQSLT), was defined as a self-reported attempt to quit SLT use within the past 12 months, regardless of outcome. For adults currently using SLT at the time of survey, this was based on the question: ‘During the past 12 months, have you tried to stop using smokeless tobacco?’ with responses recorded as either ‘yes’ or ‘no’. Adults who used SLT in the past but not at the time of survey, and reported quitting less than a year ago, were also included and considered to have made a quit attempt.

Explanatory independent variables

The explanatory variables included key demographic and socioeconomic characteristics: age (15–24, 25–34, 35–44, and ≥45 years), sex (male, female), residence (urban, rural), education level (re-categorized into four categories of no formal education, primary or lower including those with any formal education up to completing primary school, secondary or lower including those continued education into secondary or high school up to graduation from high school, and higher education including any formal education after high school), employment status (recategorized into two categories of employed including any type of employment and unemployed/other including unemployed, homemaker, student, retired, and other), and Wealth index (low, medium, high)21. Wealth index was originally created by GATS using principal component analysis (PCA) based on the respondent’s ownership of certain household items20.

Smokeless tobacco-related independent variables

Several smokeless tobacco (SLT)-specific variables were included. Participants were asked whether a doctor or healthcare provider advised them to stop using SLT in the past 12 months (yes, no). Awareness of health warnings on SLT product packaging was also recorded as a dichotomous variable (yes, no).

Exposure to anti-SLT messaging was assessed across three channels: print media (newspapers, magazines, posters, billboards), digital media (TV, radio), and other sources (unspecified). Each was analyzed separately as a dichotomous variable (yes, no).

Exposure to pro-SLT messaging was assessed via multiple sources including traditional media (e.g. print, radio, cinema), public spaces (walls, transport, clothing), and (in Wave 2) the internet. These were combined into a single dichotomous variable indicating any pro-SLT exposure in the past 30 days (yes, no), due to overlap and low response frequencies for individual sources.

Statistical analysis

Analyses were conducted using STATA version 17, with a significance level set at α=0.05. The datasets were reviewed for completeness, cleaned, and used to generate descriptive statistics such as frequencies and percentages.

Changes in: 1) the total number of participants, 2) the number and percentage of adults who used SLT currently or during last 12 months, and 3) the number and percentage of those who provided valid responses to the AQSLT question, were calculated. Relative changes (RCs) were also calculated to assess the size of change using the formula: [(Percentage in Wave 2 - Percentage in Wave 1)/Percentage in Wave 1] × 100. Z-tests were used to test for significance of the changes. Differences in sample composition across categories of explanatory variables between Wave 1 and Wave 2 were assessed using chi-squared tests and RC calculations.

Multivariate logistic regression models were used to identify factors associated with AQSLT in each wave, adjusting for all explanatory variables. Adjusted odds ratios (AORs) with 95% confidence intervals are reported. Sample weights provided by GATS were applied to account for complex survey design and ensure nationally representative estimates. Variance inflation factors (VIFs) were examined to assess multicollinearity among independent variables; no concerns were identified (all VIFs <10). RCs and z-tests were also applied to evaluate changes in AQSLT percentages within each category of explanatory variables between waves.

Finally, as the main analysis, a multivariate decomposition analysis based on logit models21,22 was conducted to examine the contribution of each factor to the overall change in AQSLT between the two waves. This analysis decomposes the change into three components:

  • Endowment effect (E): change due to differences in sample characteristics (e.g. more rural respondents)

  • Composition effect (C): change due to shifts in behaviors or attitudes within categories (e.g. rural respondents more likely to try quitting)

  • Residual effect (R): unexplained variation not captured by E or C.

RESULTS

Sample overview

In India, the total GATS sample size increased from 69296 in Wave 1 to 74037 in Wave 2, representing an RC of 6.84% (p<0.001). In Bangladesh, the sample also grew significantly from 9629 in Wave 1 to 12783 in Wave 2 (RC=32.76%’ p<0.001) (Table 1).

Table 1

Assessing the change in characteristics of participants in samples of Wave 1 (2009–2010) to Wave 2 (2016–2017) in India and Bangladesh from the Global Adult Tobacco Survey (GATS)

CharacteristicsIndiaBangladesh
Wave 1Wave 2RC%p aWave 1Wave 2RC%p a
nPercent of all participants (95% CI)nPercent of all participants (95% CI)nPercent of all participants (95% CI)nPercent of all participants (95% CI)
Total number of participants in GATS69296-74037-6.84<0.0019629-12783-32.76<0.001
Number of adults who used SLT currently or during last 12 months1725824.90 (24.53–25.28)1548020.91 (20.58–21.24)-16.02<0.001269027.94 (26.89–29.01)311924.40 (23.55–25.27)-12.67<0.001
Number of valid responses to AQSLT in the past 12 months Question1716124.76 (24.40–25.15)1547020.89 (20.57–21.23)-15.63<0.001268127.84 (26.80–28.92)311624.38 (23.55–25.25)-12.43<0.001
Sample characteristics among those with AQSLT valid responses
Explanatory/smoking-related independent variablen of categoryPercent of total (95% CI)n of categoryPercent of total (95% CI)RC%p bn of categoryPercent of total (95% CI)n of categoryPercent of total (95 % CI)RC%p b
Total17161100154701000-268110031161000-
Age (years)
15–24209412.20 (11.68–12.74)12448.04 (7.60–8.50)-34.10<0.0011405.22 (4.40–6.16)1043.34 (2.73–4.04)-36.02<0.001
25–34457626.67 (25.90–27.45)384124.83 (24.05–25.63)-6.9051619.25 (17.62–20.98)56918.26 (16.79–19.82)-5.14
35–44470127.39 (26.62–28.19)418827.07 (26.26–27.9)-1.1775828.27 (26.30–30.36)78525.19 (23.46–27.02)-10.89
≥45579033.74 (32.88–34.62)619740.06 (39.07–41.07)18.73126747.26 (44.69–49.93)165853.21 (50.68–55.83)12.59
Sex
Female672539.19 (38.26–40.14)567536.68 (35.74–37.65)-6.40<0.001143853.64 (50.90–56.48)194962.55 (59.80–65.39)16.62<0.001
Male1043660.81 (59.65–61.99)979563.32 (62.07–64.58)4.13124346.36 (43.82–49.01)116737.45 (35.33–39.66)-19.22
Residence
Urban503329.33 (28.52–30.15)369623.89 (23.13–24.67)-18.55<0.001116143.30 (40.85–45.87)135743.55 (41.26–45.93)0.580.851
Rural1212870.67 (69.42–71.94)1177476.11 (74.74–77.50)7.70152056.70 (53.88–59.62)175956.45 (53.84–59.15)-0.44
Education level
No formal schooling579933.90 (33.03–34.78)495032.02 (31.13–32.92)–5.55<0.001146355.15 (52.36–58.05)147847.43 (45.04–49.91)-14.00<0.001
Primary (or lower)499229.18 (28.38–30.00)468630.31 (29.45–31.19)3.8771526.95 (25.01–29.00)95330.58 (28.67–32.59)13.47
Secondary (or lower)439525.69 (24.94–26.46)421827.28 (26.47–28.12)6.1938114.36 (12.96–15.58)55617.84 (16.39–19.39)24.23
Higher education192211.23 (10.74–11.75)160610.39 (9.89–10.91)-7.48943.54 (2.86–4.34)1294.14 (3.46–4.92)16.95
Employment status
Unemployed/other590334.40 (33.53–35.29)456529.51 (28.66–30.38)-14.22<0.001142753.23 (50.50–56.06)188969.62 (57.92–63.42)30.79<0.001
Employed1125865.6 (64.40–66.83)1090570.49 (69.17–71.83)7.45125446.77 (44.22–49.44)122739.38 (37.20–41.64)-15.80
Wealth index
Low1042660.75 (59.9–61.93)1035266.92 (65.63–68.22)10.16<0.001136450.88 (48.21–53.65)160551.51 (49.02–54.09)1.240.006
Medium266915.56 (14.97–16.15)220314.24 (13.65–14.85)-8.4849018.28 (16.69–19.97)65120.89 (19.32–22.56)14.28
High406623.69 (22.97–24.33)291518.84 (18.17–19.54)-20.4782730.85 (28.78–33.20)86027.60 (25.79–29.51)-10.53
Advised by a doctor or healthcare provider to quit SLT in the past 12 months
No1508087.87 (86.48–89.29)1327985.84 (84.38–87.31)-2.31<0.001205076.46 (73.19–79.85)285791.69 (88.36–95.11)19.92<0.001
Yes208112.13 (11.61–12.66)219114.16 (13.58–14.77)16.7463123.54 (21.74–25.45)2598.31 (7.33–9.39)-64.7
Noticed any health warning on SLT products
No689240.18 (39.24–41.14)473430.61 (29.74–31.49)-23.82<0.001245591.57 (87.98–95.27)131142.07 (39.83–44.41)-54.06<0.001
yes1026059.82 (58.67–60.99)1073469.39 (68.09–70.72)16.02268.43 (7.37–9.60)180557.93 (55.29–60.66)587.19
Noticed any information on print media related to dangers of SLT
No899265.48 (64.13–66.84)890058.32 (57.11–59.54)-10.93<0.001241690.12 (86.56–93.78)265385.14 (81.93–88.44)-5.53<0.001
Yes474134.52 (33.55–35.52)636141.68 (40.66–42.72)20.742659.88 (8.73–11.15)46314.86 (13.54–16.28)50.4
Noticed any information on digital media related to dangers of SLT
No753954.22 (53.00–55.46)705746.55 (45.47–47.65)-14.15<0.001201775.23 (71.99-78.59)231174.17 (71.17–77.25)-1.410.351
Yes636645.78 (44.66–46.92)810353.45 (52.29–54.63)16.7566424.77 (22.92–26.72)80525.83 (24.08–27.67)4.28
Noticed any information anywhere else related to dangers of SLT
No1668097.24 (95.77–98.72)1534299.18 (97.62–100.79)2.0<0.001266199.25 (95.52–103.1)309599.33 (95.86–102.89)0.080.744
Yes4742.76 (2.52–3.02)1270.82 (0.68–0.98)-70.29200.75 (0.46–1.15)210.67 (0.42–1.03)-10.67
Exposure to pro-SLT advertisements or signs
No1386280.82 (79.48–82.18)1167575.47 (74.11–76.86)-6.62<0.001225584.11 (80.67–87.66)286091.78 (88.45–95.21)9.12<0.001
Yes329019.18 (18.53–19.85)379424.53 (23.75–25.32)27.8942615.89 (14.42–17.47)2568.22 (7.24–9.29)-48.27

RC%: relative change=[Wave 2(%) – Wave 1(%)/Wave 1(%)] × 100. AQSLT: attempted to quit smokeless tobacco (adults who currently used SLT and tried to stop smoking in the past 12 months).

a Z-test.

b Chi-squared test, for contingencies testing the differences in the characteristics of participants between Wave 1 and Wave 2. Analyses in Tables 1 and 3 were conducted to help understanding the contribution of background factors to changes in AQSLT in the multivariate decomposition analysis. Estimates reflect the analytical sample used for decomposition and may differ slightly from nationally weighted GATS percentages. p<0.05 statistically significant.

The prevalence of adults who used SLT currently or during the last 12 months declined in both countries. In India, it decreased from 24.90% in Wave 1 to 20.91% in Wave 2 (RC= -16.02%, p<0.001). In Bangladesh, it dropped from 27.94% to 24.40% (RC= -12.67%, p<0.001).

The number of adults with valid responses to the AQSLT question closely matched the total number of those who used SLT either currently or in the past 12 months across both waves, with minimal exclusions due to missing or refused responses. The rate of such exclusions was lower in Wave 2 for both countries.

Sample characteristics differences between Wave 1 and Wave 2

In India, statistically significant shifts were observed across all sample characteristics and smokeless tobacco-related independent variables (p<0.001 for all). The largest relative change (RC= -34.10%) occurred in the youngest age group (15–24 years). A smaller decrease was noted in the 25–34 age group (RC= -6.90%), while the 35–44 group showed a minimal increase (RC= -1.17%). The ≥45 years age group was the only age category with an increase in proportion (RC=18.73%). Bangladesh experienced the same pattern of change within its age groups (Table 1).

In India, significant increases were seen in the proportions of respondents who reported noticing health warnings on SLT products, exposure to anti-SLT messages in print media, and exposure to such messages in digital media. Interestingly, there was also an increase in reported exposure to pro-SLT advertisements and promotional content.

In Bangladesh, differences in place of residence, exposure to anti-SLT information via digital media, and noticing SLT-related information through other unspecified sources were not statistically significant. Other sample characteristics and SLT-related variables did show significant changes between the two waves.

Association between independent variables and AQSLT within Wave 1 and Wave 2

In India, all older age groups had significantly lower adjusted odds ratios (AORs) for AQSLT compared to the youngest group (aged 15–24 years), with p<0.003 across all categories (Table 2). In Bangladesh, same pattern of AORs was observed; however, they did not reach statistical significance.

Table 2

Associated factors of attempts to quit smokeless tobacco (AQSLT) across two waves of Global Adult Tobacco Survey (GATS) in India (2009–2010, N=12434; 2016–2017, N=15069) and Bangladesh (2009, N=2653; 2017, N=1993) based on multivariate logistic regression models adjusted for GATS weight and strata

Independent factorsIndiaBangladesh
Wave 1Wave 2Wave 1Wave 2
AORp95% CIAORp95% CIAORp95% CIAORp95 % CI
LowerUpperLowerUpperLowerUpperLowerUpper
Age (years)
15–24 ®1.001.001.001.00
25–340.820.0030.720.940.920.2800.801.070.890.6710.511.540.840.5830.441.59
35–440.790.0010.700.910.860.0440.750.990.880.6410.521.500.880.7000.471.65
≥450.79<0.0010.690.900.800.0020.690.920.600.0580.351.020.800.4800.431.49
Gender
Female ®1.001.001.001.00
Male0.990.8760.891.100.970.5030.881.060.680.0370.480.980.770.1840.521.13
Residence
Urban1.001.001.001.00
Rural0.940.1590.861.020.84<0.0010.770.910.730.0150.570.940.8000.1000.611.04
Education level
No formal education ®1.001.001.001.00
Primary0.930.1970.831.041.060.2610.961.171.050.7600.791.391.010.9460.771.33
Secondary1.040.5520.921.171.21<0.0011.091.341.440.0580.992.101.000.9810.711.42
Higher education1.090.2730.941.271.32<0.0011.151.531.220. 5580.632.381.340.4220.662.72
Employment status
Unemployed/other ®1.001.001.001.00
Employed1.090.0840.991.211.090.0710.991.201.220.2940.841.760.760.1760.501.13
Wealth index
Low ®1.001.001.001.00
Medium0.980.6870.881.091.150.0091.041.280.780.1340.561.080.910.5260.671.23
High0.83<0.0010.750.921.000.9280.901.120.820.1920.611.101.180.2750.871.60
Advised by a doctor or healthcare provider on quitting SLT in the past 12 months
No ®1.001.001.001.00
Yes2.50<0.0012.242.792.53<0.0012.302.782.16<0.0011.642.831.020.9510.621.67
Noticed any health warning on SLT products
No ®1.001.001.001.00
Yes1.41<0.0011.291.551.150.0021.051.251.260.2590.841.901.330.0201.041.69
Noticed any information on print media related to dangers of SLT
No ®1.001.001.001.00
Yes1.32<0.0011.201.451.29<0.0011.181.410.830.4090.541.281.99<0.0011.402.82
Noticed any information on digital media related to dangers of SLT
No ®1.001.001.001.00
Yes1.120.0171.021.221.080.0980.991.181.75<0.0011.312.340.660.0070.490.89
Noticed any information on anywhere else related to dangers of SLT
No ®1.001.001.001.00
Yes1.070.5470.861.321.560.0171.082.252.950.1020.8110.771.660.4890.406.95
Exposure to pro-smokeless tobacco advertisement
No ®1.001.001.001.00
Yes1.180.0011.071.291.130.0061.031.232.40<0.0011.783.261.290.2450.842.00

[i] SLT: smokeless tobacco, AOR: adjusted odds ratio. Individuals with missing responses for any variable included in this model were excluded from the analysis. ® Reference categories. p<0.05 statistically significant.

Male participants had a significantly lower likelihood of attempting to quit only in Wave 1 in Bangladesh (AOR=0.68; 95% CI: 0.48–0.98, p=0.037). Rural residence was associated with significantly lower odds of AQSLT in Wave 2 of India (AOR=0.84; 95% CI: 0.77–0.91, p<0.001) and Wave 1 of Bangladesh (AOR=0.73; 95% CI: 0.57–0.94, p=0.013). In Wave 2 of India, individuals with secondary or higher level of education had significantly greater odds of AQSLT compared to those with no formal schooling and primary education. Also, those in the medium Wealth index category were more likely to AQSLT than those in both low and high wealth categories.

Receiving advice from a healthcare provider to quit SLT within the past 12 months was strongly associated with AQSLT, with individuals who received such advice being more than twice as likely to report a quit attempt in Wave 1 (AOR=2.50; 95% CI: 2.24–2.79) and Wave 2 of India (AOR=2.53; 95% CI: 2.30–2.78) with a p<0.001 for both and Wave 1 of Bangladesh (AOR=2.16; 95% CI: 1.64–2.84, p<0.001).

Noticing health warnings on SLT product packaging and anti-SLT messages in print media was positively associated with AQSLT in both waves in India, and in Wave 2 in Bangladesh. Exposure to digital media warnings was significantly associated with higher odds of AQSLT in Wave 1 of both countries. However, this association disappeared in Wave 2 of India and reversed in Wave 2 of Bangladesh (AOR=0.66; 95% CI: 0.49–0.89, p=0.007).

Noticing SLT-related warnings from other unspecified sources was significantly associated with AQSLT only in Wave 2 of India (AOR=1.56; 95% CI: 1.08–2.25, p=0.017), at a time when digital media-specific warnings no longer showed a significant effect. This may point to the growing influence of broader or less traditional media channels not captured in media specific questions of GATS questionnaire.

Interestingly, exposure to pro-SLT advertisements was also associated with a higher likelihood of AQSLT in both waves of India and in Wave 1 of Bangladesh, a counterintuitive finding that may reflect increased awareness or cognitive dissonance rather than promotion-induced behavior.

Shifts in AQS in total and within each category of independent variables from Wave 1 to Wave 2

Both India (RC=0.66%) and Bangladesh (RC=5.79%) experienced small, non-significant increases in overall AQSLT prevalence between Wave 1 and Wave 2 (Table 3).

Table 3

Assessing the change in prevalence of attempts to quit smokeless tobacco (AQSLT) in total and by explanatory and SLT-related independent variables in the past 12 months among adults who currently smoked in India and Bangladesh from Global Adult Tobacco Survey (GATS) Wave 1 (2009–2010) to Wave 2 (2016–2017)

Explanatory/smoking-related independent variableIndiaBangladesh
Wave 1Wave 2RC% of AQSLTp* (AQSLT change)Wave 1Wave 2RC% of AQSLTp* (AQSLT change)
n of AQSLTPercent in category (95% CI)n of AQSLTPercent in category (95% CI)n of AQSLTPercent in category (95% CI)n of AQSLTPercent in category (95 % CI)
Total: Individuals who attempted to quit SLT in the past 12 months510429.74 (28.93–30.57)463129.94 (29.08–30.81)0.670.70474527.79 (25.83–29.86)91629.40 (27.52–31.36)5.790.177
Age (years)
15–2472334.53 (30.06–37.14)41032.96 (29.84–36.31)–4.760.3524935.00 (25.89–42.67)2826.92 (17.89–38.91)-23.140.180
25–34141430.90 (29.31–32.55)123132.05 (30.28–33.89)3.720.25816932.75 (28.00–38.08)17130.05 (25.72–34.91)-8.230.337
35–44138329.42 (27.89–31.01)127930.54 (28.89–32.26)3.810.25023130.47 (26.67–34.67)24631.34 (27.54–35.51)2.620.407
≥45158427.36 (26.03–28.74)171127.61 (26.32–28.95)0.9140.75729623.36 (20.78–26.18)47128.41 (25.90–31.09)21.370.002
Sex
Female182827.18 (25.95–28.46)154327.19 (25.85–28.58)0.040.99233623.37 (20.93–26.00)28914.83 (13.17–16.64)-8.150.020
Male327631.39 (30.33–32.49)308831.53 (30.42–32.66)0.450.83440932.90 (29.79–36.25)62753.73 (49.60–58.1)13.380.204
Residence
Urban163232.43 (30.87–34.04)128934.88 (33.00–36.83)7.550.01636631.52 (28.38–34.93)45633.6 (30.59–36.83)6.670.267
Rural347228.63 (27.68–29.60)334228.38 (27.43–29.36)–0.870.67437924.93 (22.49–27.58)46026.15 (23.82–28.65)5.220.424
Education level
No formal schooling151126.06 (24.76–27.40)123624.97 (23.60–26.40)–4.180.19737325.50 (22.97–28.22)40627.47 (24.86–30.28)7.840.267
Primary (or lower)143828.81 (27.34–30.33)137329.30 (27.77–30.89)1.700.59620528.67 (24.88–32.88)26828.12 (24.86–31.70)-2.090.803
Secondary (or lower)136933.42 (31.74–35.18)142033.67 (31.94–35.46)0.750.81013334.91 (29.23–41.37)19134.35 (29.65–39.58)-1.430.857
Higher education67335.02 (32.42–37.76)59937.30 (34.37–40.41)6.510.1593436.17 (25.05–30.55)5139.53 (29.44–51.98)9.120.610
Employment status
Unemployed/other162127.46 (26.14–28.83)124527.27 (25.78–28.83)–0.690.83439527.68 (25.02–30.55)59231.34 (28.87–33.97)13.000.023
Employed348330.94 (29.92–31.98)338631.05 (30.01–32.11)0.360.85735027.91 (25.06–30.99)32426.41 (23.61–29.44)-5.380.401
Wealth index
Low299528.73 (27.71–29.77)288227.84 (26.83–28.88)–3.100.15636026.39 (23.74–29.27)43326.98 (24.50–29.64)2.270.719
Medium86132.26 (30.14–34.49)76234.59 (32.18–37.13)7.220.08512325.10 (20.86–29.95)18528.42 (24.47–32.82)13.150.211
High124830.69 (29.01–32.44)98733.86 (31.78–36.04)10.330.00526231.68 (27.96–35.76)29834.65 (30.83–38.82)9.460.194
Advised by a doctor or healthcare provider to quit SLT in the past 12 months
No411527.29 (26.46–28.13)357026.88 (26.01–27.78)-1.500.44748323.56 (21.51–25.76)82328.81 (26.87–30.84)22.03<0.001
Yes98947.53 (44.61–50.58106148.43 (45.56–51.43)1.890.55526241.52 (36.65–46.87)9335.91 (28.98–43.99)-13.490.121
Noticed any health warning on SLT products
No165223.97 (22.83–25.15)117124.74 (23.34–26.19)3.210.34265626.72 (24.72–28.85)35226.85 (24.12–29.81)0.370.928
Yes344733.60 (32.48–34.74)346032.23 (31.17–33.33)-4.080.0368939.38 (31.63–48.46)56431.25 (28.72–33.94)-20.810.013
Noticed any information on print media related to dangers of SLT
No246927.46 (26.39–28.56)228325.65 (24.61–26.73)-6.590.00664526.7 (24.68–28.84)72627.37 (25.41–29.43)2.620.596
Yes180037.97 (36.23–39.76)231036.32 (34.85–37.83)-4.350.07510037.74 (30.7–45.9)19041.04 (35.41–47.30)8.750.379
Noticed any information on digital media related to dangers of SLT
No205527.26 (26.09–28.46)180425.56 (24.40–26.77)-6.240.02049624.59 (22.47–26.85)65728.43 (26.30–30.69)15.450.004
Yes219734.51 (33.08–35.99)277034.18 (32.92–35.48)-0.960.68224937.5 (32.99–42.46)25932.17 (28.37–36.34)-14.130.032
Noticed any information anywhere else related to dangers of SLT
No492329.51 (28.70–30.35)457629.83 (28.97–30.70)1.080.54273427.58 (25.62–29.65)90529.24 (27.37–31.21)5.800.164
Yes17837.55 (32.24–43.49)5543.31 (32.62–56.37)15.340.2381155.00 (27.46–98.41)1152.38 (26.15–93.72)8.000.865
Exposure to pro-SLT advertisement
No390128.14 (27.27–29.04)328728.15 (27.20–29.13)0.040.98455724.70 (22.69–26.84)80928.29 (26.37–30.30)14.530.004
Yes119836.41 (34.38–38.54)134435.42 (33.56–37.37)-2.720.38418844.13 (38.05–50.91)10741.80 (34.25–50.51)-5.280.548

RC%: relative change=[Wave 2(%) – Wave 1(%)/Wave 1(%)] × 100. AQSLT: attempted to quit smokeless tobacco (adults who currently used smokeless tobacco and tried to stop smoking in the past 12 months).

* p-values are obtained using z-tests, testing the difference in percentages between Wave 1 and Wave 2 of each row. Analyses in Tables 1 and 3 were conducted to help understanding the contribution of background factors to changes in AQSLT in the multivariate decomposition analysis. Estimates reflect the analytical sample used for decomposition and may differ slightly from nationally weighted GATS percentages. Statistically significant p<0.05.

Among the explanatory independent variables, India showed two significant increases in AQSLT: among urban residents (RC=7.55%, p=0.016) and individuals in the high wealth index category (RC=10.33%, p=0.005).

In Bangladesh, a significant increase in AQSLT was observed in the ≥45 years age group, rising from 23.36% in Wave 1 to 28.41% in Wave 2 (RC=21.37%, p=0.002). Bangladeshi females showed a significant decline in AQSLT, dropping from 23.37% to 14.83% (RC= -8.15%, p=0.020). A significant increase was also seen among the unemployed/other group in Bangladesh (RC=13.00%, p=0.023).

Among SLT-related variables, AQSLT prevalence remained stable in India for both those who did and did not receive professional advice to quit. However, in Bangladesh, a significant increase was found among those who did not receive advice, from 23.56% to 28.81% (RC=22.03%, p<0.001). Interestingly, AQSLT among those who received such advice declined, although the change was not statistically significant.

AQSLT rates decreased significantly among those who noticed health warnings on SLT products in both India (RC= -4.08%, p=0.036) and Bangladesh (RC= -20.81%, p=0.013). Similarly, a significant decrease was observed in Bangladesh among those who reported exposure to SLT-related messages via digital media (RC= -14.13%, p=0.032).

In terms of exposure to pro-SLT advertising, Bangladesh showed a significant increase in AQSLT among those not exposed to such advertisements from 24.70% in Wave 1 to 28.29% in Wave 2 (RC=14.53%, p=0.004).

Overview of relative contribution of predictors to change in AQSLT from Wave 1 to Wave 2

The first section of Table 4 presents the relative contributions of the endowment effect (E), composition effect (C), and residual effect (R) to changes in AQSLT prevalence between Wave 1 and Wave 2 in India and Bangladesh. None of the components showed statistically significant total contributions. However, the E and C components were further examined, as it remained possible that significant contributions by specific factors, either due to changes in sample characteristics (E) or shifts in behaviors within specific categories (C), happened but were offset by opposing effects elsewhere. This was particularly relevant given the overall non-significant change in AQSLT prevalence (Table 3).

Table 4

Relative contribution of predictors to the change in attempts to quit smokeless tobacco (AQSLT) between Wave 1 (2009–2010) and Wave 2 (2016–2017) of Global Adult Tobacco Survey (GATS) in India (N=32631) and Bangladesh (N=5797) using multivariate decomposition analysis

IndiaBangladesh
Coef.p95% CPercent*Coef.p95% CPercent*
LowerUpperLowerUpper
E-0.002480.283-0.007000.0020426.520.01450.178-0.00660.0356110.28
C-0.006860.248-0.018500.0047773.48-0.00140.931-0.03210.0294-10.28
R-0.009340.087-0.020040.001360.01320.256-0.00960.0359
Endowment effect (E)
Age (years)
15–24
25–340.000400.297-0.000350.00115-4.26-0.00040.428-0.00150.0006-3.28
35–440.000290.066-0.000020.00059-3.06-0.00170.236-0.00440.0011-12.55
≥45-0.003650.007-0.00632-0.0019839.080.00280.313-0.00260.008321.31
Gender
Female
Male0.000060.503-0.001120.00024-0.660.00780.0020.00290.012658.91
Residence
Urban
Rural-0.003090.001-0.00497-0.0012133.070.00010.0030.000030.00010.63
Education level
No education
Primary (or less)-0.000070.264-0.000180.000050.720.00020.825-0.00120.00151.17
Secondary (or less)-0.001120.002-0.00181-0.0004312.000.00170.0450.000040.003312.59
Higher education-0.002080.001-0.00332-0.0008522.310.00040.114-0.00010.00093.83
Employment status
Unemployed/other
Employed0.000590.079-0.000070.00126-6.360.00150.433-0.00230.005411.69
Wealth index
Low
Medium-0.001080.019-0.00199-0.0001711.61-0.000030.960-0.00120.0011-0.22
High-0.000100.928-0.002260.002061.06-0.00100.131-0.00240.0003-7.90
Advised by a doctor or healthcare provider on quitting SLT in the past 12 months
No
Yes0.00278<0.0010.002050.00351-29.76-0.00560.216-0.01440.0033-42.37
Noticed any health warning on SLT products
No
Yes0.002120.0030.000720.00352-22.710.00950.256-0.00690.025972.22
Noticed any information on print media related to dangers of SLT
No
Yes0.00289<0.0010.001720.00407-30.980.0056<0.0010.00320.007942.34
Noticed any information on digital media related to dangers of SLT
No
Yes0.001030.082-0.000130.00219-11.05-0.00030.064-0.00060.00002-2.27
Noticed any information anywhere else related to dangers of SLT
No
Yes-0.001910.053-0.003840.0000320.42-0.00010.218-0.00020.0001-0.66
Exposure to pro-SLT advertisements
No
Yes0.000460.0110.000110.00081-4.93-0.00580.005-0.0092-0.0018-44.35
Total26.52110.28
Coefficient effect (C)
Age (years) 15–24
25–340.006810.247-0.004710.01834-72.95-0.00290.944-0.08360.0779-21.88
35–440.005040.402-0.006740.01681-53.91-0.00690.944-0.20140.1875-52.75
≥450.000910.886-0.011530.01336-9.77-0.01780.944-0.51590.4804-135.16
Gender
Female
Male-0.003290.735-0.022340.0157735.190.00570.945-0.1550.166743.45
Residence
Urban
Rural-0.016130.063-0.033140.00089172.620.00120.945-0.03180.03418.78
Education level
No education
Primary (or less)0.008660.097-0.001560.01888-92.730.00090.944-0.02430.02616.82
Secondary (or less)0.009900.069-0.000750.02056-106.010.00060.944-0.01730.01864.88
Higher education0.006010.069-0.000460.01249-64.370.00010.947-0.00260.00280.70
Employment status
Unemployed/other
Employed-0.000210.983-0.020020.019592.280.00430.944-0.11450.123132.41
Wealth index
Low
Medium0.006350.0400.000280.01242-68.01-0.00150.944-0.04480.0417-11.75
High0.012490.0160.002310.02268-133.75-0.00200.944-0.05730.0533-15.02
Advised by a doctor or healthcare provider on quitting SLT in the past 12 months
No
Yes0.000340.860-0.003460.00414-3.660.00750.944-0.20430.219457.30
Noticed any health warning on SLT products
No
Yes-0.027140.007-0.04679-0.00749290.540.00040.943-0.00940.01012.72
Noticed any information on print media related to dangers of SLT
No
Yes-0.001630.750-0.011640.0083917.43-0.00300.944-0.08690.0809-22.78
Noticed any information on digital media related to dangers of SLT
No
Yes-0.003290.600-0.015590.0090035.270.00610.944-0.16510.177446.53
Noticed any information anywhere else related to dangers of SLT
No
Yes0.002530.076-0.000260.00531-27.030.00010.945-0.00290.00310.80
Exposure to pro-SLT advertisements
No
Yes-0.002130.504-0.008360.0041022.750.00250.944-0.06750.072518.92
Total73.48-10.28

Coef: coefficient.

* Percentage contribution. E: endowment effect. C: contribution effect. R: residual effect. Statistically significant p<0.05.

Endowment effect: contributions to AQSLT change by change in sample characteristics

Despite significant differences in age distribution from Wave 1 to Wave 2 within both countries (Table 1), the multivariate decomposition revealed that the only significant contribution was made by the increase in the ≥45 years age group, which had a significant negative effect on the total AQSLT in India (percent contribution=39.08%, p=0.007) (Table 4). In terms of sex, a significant contribution was observed in Bangladesh, where the lower percentage of males in Wave 2 had a positive effect, equal to 58.91% of the total AQSLT change (p=0.002). For residence, the decreased proportion of urban residents in Wave 2 of India negatively influenced AQSLT change (33.07%, p<0.001). In contrast, a modest but significant positive contribution of 0.63% was seen in Bangladesh related to change in residence (p=0.003).

Significant endowment contributions to the total AQSLT were also observed within education categories of both countries and Wealth index of India.

In India, the increase in the proportion of individuals receiving quitting advice from doctors or health professionals from Wave 1 to Wave 2, and the increase in those noticing health warnings on SLT products, both had significant positive contributions towards total AQSLT change, accounting for 29.76% (p<0.001) and 22.71% (p=0.003) of total change, respectively. However, the change proportion of participant in neither of these factors had significant contribution in Bangladesh.

In terms of media exposure, the contribution to AQSLT change from Wave 1 to Wave 2 in India was only significant in those who noticed information related to danger of SLT in print media, which was positive in both India (30.98%, p<0.001) and Bangladesh (42.34%, p<0.001).

Table 2 presented the interesting fact that those exposed to pro-SLT advertisements and promotions were more like to AQSLT. This was resonated in endowment effect as in India, increased exposure to these advertisements from Wave 1 to Wave 2 had a significant positive contribution to total AQSLT change (4.93%, p=0.011), while in Bangladesh, decreased exposure resulted in a significant negative contribution (44.35%, p=0.005) after adjustments were made.

Composition effect: changes in respondent attitudes on AQSLT from Wave 1 to Wave 2

The only two variables with a significant composition effect on total AQSLT change in India were the Wealth index and noticing health warnings on SLT products (Table 4). Individuals in the medium and high Wealth index categories showed increased AQSLT rates between waves, which contributed positively to the overall change – 68.01% (p=0.040) for the medium and 133.75% (p=0.016) for the high Wealth index group. In contrast, a significant decline in AQSLT among those who noticed health warnings on SLT products contributed negatively. This single factor accounted for a large negative contribution of 290.54% (p=0.007) to the total AQSLT change. In Bangladesh, no single variable had a significant composition effect, with most p-values being close to 1.

DISCUSSION

This study provides a comparative analysis of quit attempts among adults using SLT in India and Bangladesh, using two waves of nationally representative GATS data. Despite a significant reduction in the overall prevalence of SLT use between waves, the percentage of AQSLT showed only small, non-significant increases in both countries from Wave 1 to Wave 2.

The Longitudinal Aging Study in India (LASI) reported a prevalence of current SLT use of 17.2% among older adults, which is substantially lower than the proportions observed in the GATS data used in this study23. This discrepancy may reflect differences in sampling design, self-reporting accuracy, or broader definitions of SLT use across surveys, but it also highlights the continued high burden of SLT use among Indian adults, particularly beyond middle age23.

The finding that females constitute a large proportion of SLT users in Bangladesh contrasts with tobacco smoking patterns, where, based on previous studies using the same GATS data, females made up only a small fraction of adults who smoked tobacco21.

The pattern of change within the age groups in India suggests that the overall decline in the proportion of adults who used SLT currently or during the last 12 months in Wave 2 compared to Wave 1 of India might have primarily been driven by reduced initiation among younger participants, rather than cessation among older age groups. Older adults consistently exhibited lower odds of AQSLT, particularly in India, where the endowment effect of an increased ≥45 years age group negatively impacted total AQSLT. This aligns with existing literature indicating that older adults using SLT are less likely to attempt quitting and may require targeted interventions to overcome entrenched behaviours24.

Education was positively associated with quit attempts, particularly in Wave 2 of India, and decomposition analysis supported a positive contribution of higher level of education to AQSLT. These findings corroborate earlier studies suggesting higher level of education enhances health literacy and readiness to quit SLT25,26.

In Bangladesh, significant gender disparities emerged, with a decline in AQSLT among females despite an increasing share of women in the SLT-using population. This suggests a need for gender-sensitive interventions. While previous data from NFHS-4 showed Indian women were less likely to intend or succeed in quitting SLT27, the current findings indicate that in Bangladesh, this trend may be even more pronounced.

Advice from healthcare providers was a strong and consistent predictor of AQSLT in both waves of India and Wave 1 of Bangladesh. However, the unchanged quit attempt rates among those who did and did not receive advice in India suggest gaps in either the frequency or quality of cessation support. As previous studies suggest, routine integration of tobacco use history and quit support in primary care can play a transformative role28.

Exposure to anti-SLT warnings had mixed effects. While associated with higher odds of quit attempts in some groups (e.g. print media in India), decomposition analysis showed a negative contribution from those who noticed SLT warnings on packaging – especially in India. This may indicate that warning labels are losing their impact over time, possibly due to poor design, cultural misinterpretation, or competing product packaging29. These findings are consistent with studies suggesting the need for more impactful, culturally appropriate, and regularly updated warnings30.

The most unexpected result was that exposure to pro-SLT advertising was associated with higher AQSLT odds in both waves of India and Wave 1 of Bangladesh. That exposure change had positive association with AQSLT in India but negative one in Bangladesh. While counterintuitive, this may reflect heightened awareness or cognitive dissonance among those exposed to conflicting messages31. It also underscores the complex role of media and the need to monitor not just the presence but also the content and framing of pro- and anti-SLT messaging31.

Despite progress in policies for tobacco control in both countries, including expanded tobacco control laws and increase in awareness campaigns, cessation support for SLT remains limited. Treatment services, especially those tailored for SLT cessation, are scarce and not evidence based. This gap may partly explain the disconnection between reduced prevalence and stagnant quit attempts. Tobacco control programs must address the serious misconceptions that SLT is harmless or helpful for health issues, particularly in rural and underserved populations7,31.

Strengths and limitations

This study’s key strength lies in the use of multivariate decomposition analysis, which allowed for a nuanced examination of both demographic shifts and behavioral change. The large, nationally representative GATS data add to the generalizability of the findings across both countries.

Limitations include the cross-sectional nature of GATS data, precluding causal inference. Composite media exposure variables may have masked specific media effects. Self-reported quit attempts are also susceptible to recall and social desirability bias. Despite the inclusion of a broad range of explanatory variables, the significant residual component (‘R’) in decomposition analysis of India likely reflects unmeasured influences on smoking cessation. Furthermore, GATS Wave 2 data predate the full-scale rollout of interventions like India’s mCessation program32, potentially underestimating the current policy impact.

Policy and practice implications

Findings highlight the importance of strengthening cessation infrastructure and support systems. Revisiting SLT cessation advice program, culturally tailored public messaging, and improving enforcement against pro-SLT advertising could help support quit attempts. Warning labels require dynamic redesign and field testing to enhance relevance and impact.

Future research

Further research could explore the effectiveness of different SLT cessation approaches, including digital and AI-based interventions. Qualitative studies targeting women and older adults that use SLT, and other marginalized groups, may uncover barriers and facilitators unique to these populations. Longitudinal data capturing transitions in SLT use and multiple quit attempts would offer deeper insights into sustained cessation trajectories.

CONCLUSIONS

There has been a modest decline in the overall prevalence of SLT use between Wave 1 and Wave 2 of GATS in India and Bangladesh. However, the proportion of adults who attempted to quit SLT remained nearly unchanged, despite substantial tobacco control efforts during the same period. Several background and socioeconomic factors appear to be influential. Although the percentages of individuals receiving professional advice or noticing warning messages increased, multivariate analysis questions their effectiveness, especially regarding the warnings in SLT products. Future research should focus on evaluating how these interventions are implemented, exploring culturally tailored approaches, and identifying communication strategies that effectively motivate quit attempts among SLT users.